The researchers said advice on taking heartburn medicine should not change, but that more research was needed.
Babies born to mothers who take heartburn medication during pregnancy could have a greater risk of developing asthma, research carried out in Scotland suggests.
A review of studies found that babies whose mothers were prescribed drugs to deal with acid reflux in pregnancy were more likely to be treated for asthma in childhood.
Heartburn is caused by stomach acid passing from the stomach back into the oesophagus, the tube that connects the stomach to the throat. It is a very common condition in pregnancy because of hormonal changes and pressure on the stomach from the foetus.
Drugs called H2-receptor antagonists and proton pump inhibitors can help to block the acid reflux. They are considered safe to use in pregnancy because they do not affect the development of the baby.
Researchers, led by the universities of Edinburgh and Tampere, in Finland, reviewed eight previous studies that had examined health records involving more than 1.3 million children.
The team found that children born to mothers who had been prescribed acid-blocking drugs during pregnancy were at least a third more likely to have visited a doctor for symptoms of asthma. The scientists said that advice for expectant mothers should not change based on the findings but that further studies were needed.
Aziz Sheikh, co-director of the Asthma UK Centre for Applied Research at the University of Edinburgh, said: “Our study reports an association between the onset of asthma in children and their mothers’ use of acid-suppressing medication during pregnancy.
“It is important to stress that this association does not prove that the medicines caused asthma in these children and further research is needed to better understand this link.”
Samantha Walker, director of policy and research at Asthma UK, said: “We don’t yet know if the heartburn medication itself is contributing to the development of asthma in children or if there is a common factor we haven’t discovered yet that causes both heartburn in pregnant women and asthma in their children.
“The study points us towards something that needs further investigation, which is why we need to see more research carried out into the causes of asthma, a condition that affects 5.4 million people in the UK alone.”
The study is published in The Journal of Allergy and Clinical Immunology.